Nucleation of lactose using continuous orifice flow |
| |
| Affiliation: | 1. School of Engineering and Advanced Technology, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand;2. DFE Pharma, P.O. Box 20 21 20, 47568 Goch, Germany;1. Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand;2. Department of Maternal Fetal Medicine, Prenatal Cell and Gene Therapy Group, Elizabeth Garrett Anderson Institute for Women’s Health, University College London, London, WC1E 6HX, United Kingdom;3. NIHR University College London Hospitals Biomedical Research Centre, 149 Tottenham Court Road, London, W1T 7DN, United Kingdom;4. Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand;5. NIHR GOS Institute of Child Health Biomedical Research Centre, University College, London, United Kingdom;6. Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom;7. Paediatric Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom;8. School of Biomedical Engineering and Imaging Sciences, Kings College London, United Kingdom;1. Department of Cell Biology, The Franciszek Gorski Institute of Plant Physiology, Polish Academy of Sciences, Niezapominajek 21, PL 30-239 Krakow, Poland;2. Department of Genetics, Physiology and Biotechnology, UTP University of Science and Technology, Prof. S. Kaliskiego Ave. 7, PL 85-789, Bydgoszcz, Poland;3. Institute of Plant Biology and Biotechnology, Faculty of Biotechnology and Horticulture, University of Agriculture in Krakow, Al. 29 Listopada 54, PL 31-425 Krakow, Poland;4. United States Department of Agriculture − Agricultural Research Service, Vegetable Crops Research Unit, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706-1590, USA;5. Institute for Breeding Research on Horticultural Crops, Julius Kühn-Institut, Federal Research Centre for Cultivated Plants, Erwin-Baur-Str. 27, DE 06-484 Quedlinburg, Germany;1. Grupo de investigación en Materiales, Catálisis y Medio ambiente, Facultad de Ingeniería, Universidad Nacional de Colombia, Carrera 45 # 26-85, 111321 Bogotá D.C., Colombia;2. Grupo de Investigación en Materiales Funcionales y Catálisis GIMFC, Departamento de Química, Universidad de Nariño, Calle 18, Cra. 50 Campus Torobajo, 520002 Pasto, Colombia;3. Centro de Estudios en Estadística CEASE, Departamento de Matemáticas y Estadística, Universidad de Nariño, Calle 18, Cra. 50 Campus Torobajo, 520002 Pasto, Colombia |
| |
| Abstract: | This paper describes two methods used to produce a constant supply of super-saturated lactose solution with nuclei already present, required as the feed stream for a new design of a continuous crystalliser. Both methods involve cooling a hot saturated lactose solution to super-saturation and then passing it through an orifice or applying mechanical agitation to initiate nucleation. Orifice Reynolds number (Re) of 500 and 1000 and wait times subsequent to cooling of 0 and 1 h were used. Wait time and Re had no effect on nuclei numbers, but a wait time at an orifice Re of 1000 increased crystal size and decreased the span of the crystal size distribution, suggesting that these conditions produced faster growing crystals. In experiments with nucleation by mechanical agitation followed by dilution, crystal numbers were several orders of magnitude lower than for orifice nucleation, and resulted in a small span. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
