Simultaneous co-substitution of Sr2+/Fe3+ in hydroxyapatite nanoparticles for potential biomedical applications |
| |
Authors: | Ismat Ullah Wenchao Li Shi Lei Yu Zhang Wancheng Zhang Umer Farooq Shafqat Ullah Muhammad Wajid Ullah Xianglin Zhang |
| |
Affiliation: | 1. State Key Laboratory of Materials Processing and Die/Mold Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China;2. Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China;3. Federal Urdu University of Arts, Science and Technology, Islamabad, Pakistan |
| |
Abstract: | In human, strontium (Sr) follows the same physiological pathway as calcium and thus could be used for improving the bioactivity and osteoconductivity of hydroxyapatite (HAp) in bone tissues. Similarly, iron (Fe) can potentially play an important role in bone remodeling due to its magnetic properties. Therefore, the current study was aimed to simultaneously co-substitute Sr2+/Fe3+ in HAp nanoparticles for various potential biomedical applications. The Sr2+/Fe3+ co-substituted HAp nanoparticles were systematically synthesized through sonication-assisted aqueous precipitation method. The as-synthesized nanoparticles were evaluated for different physicochemical and biological properties. X-ray diffraction (XRD) patterns of Sr2+/Fe3+ co-substituted HAp nanoparticles confirmed their phase purity and showed hexagonal-like structure. Scanning electron microscope (SEM) micrographs showed an agglomerated rod-like morphology of HAp nanoparticles which contained pores consisted of small spheroids. The nanoparticles displayed magnetization (Ms) reliance on the loading level of mole % (X?=?Fe3+) and exhibited tunable porosity and microhardness (Hv) upon heat treatment. The nanoparticles showed less than 5% hemolysis demonstrating high blood compatibility with high in vitro bioactivity performance. The multifunctional properties of synthesized nanoparticles make them a potential candidate for various biomedical applications; including bone grafting and guided bone regeneration, targeted drug delivery, magnetic resonance imaging, and hyperthermia based cancer treatment. |
| |
Keywords: | Hydroxyapatite Multifunctional biomaterial Paramagnetic Bioactivity |
本文献已被 ScienceDirect 等数据库收录! |
|