| High-resolution SPECT for small-animal imaging |
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| 作者姓名： | QI Yu-Jin |
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| 作者单位： | Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800, China |
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| 摘 要： | 1Introduction The rapid advance in molecular biology and the increasing use of transgenic mice as models of human biology and diseases have led to significant interests in the development of noninvasive,high-resolution,in vivo imaging techniques for small animals1-4].Medi-cal imaging techniques including ultrasound(US),computed tomography(CT),magnetic resonance im-aging(MRI),positron emission tomography(PET),and single-photon emission computed tomography(SPECT),are contributing to this …
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| 关 键 词： | 分子成像 小孔准直 γ照相机 高分辨率SPECT |
| 收稿时间： | 2006-03-06 |
High-resolution SPECT for small-animal imaging |
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| QI Yu-Jin.High-resolution SPECT for small-animal imaging[J].Nuclear Science and Techniques,2006,17(3):164-169. |
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| Authors: | QI Yu-Jin |
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| Affiliation: | Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800, China |
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| Abstract: | This article presents a brief overview of the development of high-resolution SPECT for small-animal imaging. A pinhole collimator has been used for high-resolution animal SPECT to provide better spatial resolution and detection efficiency in comparison with a parallel-hole collimator. The theory of imaging characteristics of the pinhole collimator is presented and the designs of the pinhole aperture are discussed. The detector technologies used for the development of small-animal SPECT and the recent advances are presented. The evolving trend of small-animal SPECT is toward a multi-pinhole and a multi-detector system to obtain a high resolution and also a high detection efficiency. |
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| Keywords: | Small-animal SPECT Molecular imaging Pinhole collimation Gamma camera |
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