| 氧化法制备1,2-苯并异噻唑啉-3-酮 |
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| 引用本文： | 张可青,任蕊,杨俊伟,李程碑.氧化法制备1,2-苯并异噻唑啉-3-酮[J].应用化工,2014(9):1637-1639. |
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| 作者姓名： | 张可青 任蕊 杨俊伟 李程碑 |
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| 作者单位： | 陕西省石油化工研究设计院,陕西 西安,710054 |
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| 基金项目： | 延长石油集团科技攻关项目(Ycsy2011Ky-B-112)；陕西省石油化工研究设计院青年创新基金项目 |
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| 摘 要： | 以二硫化二苯甲酸为起始原料,经酰胺化后以双氧水为氧化剂,制备1,2-苯并异噻唑啉-3-酮。结果表明,在氧化剂与酰胺的摩尔比为1.2∶1,反应时间为3 h,反应温度60℃条件下,反应总收率可达67.7%,产物熔点156~158℃。加入催化剂三乙胺,可加速反应,使得反应时间缩短为2 h,同时氧化反应产率提高为79.2%。
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| 关 键 词： | 1 2-苯并异噻唑啉-3-酮 杀菌剂 二硫化二苯甲酸 氧化反应 |
Synthesis of 1,2-benzisothiazolin-3-one by oxidation |
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| ZHANG Ke-qing,REN Rui,YANG Jun-wei,LI Cheng-bei.Synthesis of 1,2-benzisothiazolin-3-one by oxidation[J].Applied chemical industry,2014(9):1637-1639. |
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| Authors: | ZHANG Ke-qing REN Rui YANG Jun-wei LI Cheng-bei |
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| Affiliation: | (Shaanxi Research and Design Institute of Petroleum and Chemical Industry, Xi＇an 710054, China) |
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| Abstract: | 1,2-Benzisothiazdin-3-one was prepared from 2,2-dithiobis-benzoic acid by acylation,oxidation with hydrogen peroxide. The result showed that the molar ratio of oxidant and amide was 1. 2： 1,the reac-tion time was 3 h,and the reaction temperature was about 60 ℃ ,and the total yield was 67. 7% ,the melt-ing point product was 156 ~ 158 ℃. The oxidation reaction time was shortened to 2 h by the catalyst tri-ethylamine,and yield of the reaction was increased to 79. 2% as well. |
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| Keywords: | 1 2-benzisothiazolin-3-one antiseptic 2 2-dithiobis-benzoic acid oxidation |
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