抗菌肽的生物活性、作用机制及应用研究进展

抗菌肽是具有抗菌活性的一类短肽,广泛存在于生物界,是先天免疫的重要防御物质,具有广谱抗菌活性和抗病毒、抗真菌、抗寄生虫及抗肿瘤等生物活性,且不易产生抗药性,有良好的应用前景。该文对抗菌肽的生物活性、作用机理及应用现状进行了综述,并指出在开发研究抗菌肽中存在的问题,对其发展作了展望。

Bioactivity, action mechanism and application of antimicrobial peptides

Antimicrobial peptides(AMPs),a family of short-chain peptides with antibacterial activity,are widely spread in biological universe.AMPs are important defense substances in innate immune system.Except for broad-spectrum antibacterial activity,AMPs have more biological activities on the resistance of virus,fungi,parasite and tumor,but scarcely induce drug resistance,which defines a great application prospect.In this paper,the bioactivity,action mechanism and application of AMPs were summarized.Moreover,the current problems and future development were prospected.