Synthetic biological system construction and green intelligent biological manufacturing |
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| Authors: | Lei QIN Jie YU Xiaoyu NING Wentao SUN Chun LI |
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| Affiliation: | 1.Institute of Biochemical Engineering, Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.;2.Key Laboratory for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China |
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| Abstract: | The production of chemicals in microbial cell factories is one of the effective ways to solve energy and environmental problems. Many chemical products have been produced by synthetic biology, but production ability and robustness of the strains still needs to been improved. Development of intelligent cell factory and realizing intelligent biological manufacturing is an important approach to improve the production and robustness. This review introduces the research status of intelligent biological manufacturing from five following aspects: protein design, biosensor, metabolism regulation, strain evolution and fermentation process. The development of biological “intelligence” will make an important contribution to improving the production level of industrial biological processes and process energy saving and emission reduction. |
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| Keywords: | biological engineering molecular biology synthetic biology intelligence biological manufacturing robustness biosensor genetic circuit |
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