| 手性固定相反相高效液相色谱法拆分吲哚洛尔对映体 |
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| 引用本文： | 刘发现,曹雪玲,王清珊,金东日.手性固定相反相高效液相色谱法拆分吲哚洛尔对映体[J].延边大学理工学报,2007,33(1):33-36. |
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| 作者姓名： | 刘发现 曹雪玲 王清珊 金东日 |
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| 作者单位： | 延边大学理学院化学系 吉林延吉133002 |
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| 摘 要： | 采用新型商品反相手性色谱柱Chiral PAKR AD-RH,建立了β-受体阻滞剂类药物吲哚洛尔的手性拆分方法.考察了流动相组成、pH、柱温、流速及缓冲盐浓度对吲哚洛尔手性拆分的影响.通过优化实验条件,吲哚洛尔达到基线分离,可用于常规分析.在此基础上,进一步考察了制备条件,取得了满意的结果.
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| 关 键 词： | 吲哚洛尔 手性拆分 |
| 文章编号： | 1004-4353(2007)01-0033-04 |
| 修稿时间： | 2006-12-07 |
Chiral separation of pindolol by reversed-phase high performance liquid chromatography |
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| LIU Fa-xian,CAO Xue-ling,WANG Qing-shan,JIN Dong-ri.Chiral separation of pindolol by reversed-phase high performance liquid chromatography[J].Journal of Yanbian University (Natural Science),2007,33(1):33-36. |
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| Authors: | LIU Fa-xian CAO Xue-ling WANG Qing-shan JIN Dong-ri |
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| Affiliation: | Department of Chernistry, CollegeofScience, Yanbian University, YanjiJilin 133002, China |
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| Abstract: | Chiral separation of pindolol by RP-HPLC with a new chiral column Chiral PAKR AD-RH was builded.The effects of the content of mobile phase,pH,column temperature and buffer concentration on the chiral separation of pindolol were discussed.At the optimal conditions,baseline separation of pindolol was achieved.The method could be applied to routine analysis of enantiomers of pindolol and be used for preparation. |
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| Keywords: | Chiral PAKR AD-RH |
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