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Magnetic Force Microscopy of an Oxygen-Sensing Spin-Probe |
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| Authors: | Mayur Savla Ramasamy P. Pandian Periannan Kuppusamy Gunjan Agarwal |
| Affiliation: | 1. Biomedical Engineering Department, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA Veeco Instruments, Freemont, California 94538, USA;2. Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA;3. Biomedical Engineering Department, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA |
| Abstract: | In the present work we provide magnetic force microscopy (MFM) analysis on particles of a paramagnetic spin-probe lithium octa-n-butoxy-naphthalo-cyanine (LiNc-BuO) used for EPR oximetry. We demonstrate how MFM can generate a magnetic contrast in ambient air for LiNc-BuO particles when they assemble into structures >50 nm in size. The same sample when assembled into particles <10 nm in size failed to show contrast in MFM images. The potential for utilizing MFM to understand the magnetic signature of paramagnetic nanoparticles in biological samples is discussed. |
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