| 聚乙二醇及其衍生物改性生物医用材料表面的血液相容性 |
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| 引用本文： | 胡小洋,陈红,张燕霞,王艺峰,吴仲岿. 聚乙二醇及其衍生物改性生物医用材料表面的血液相容性[J]. 高分子材料科学与工程, 2007, 23(6): 127-131 |
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| 作者姓名： | 胡小洋 陈红 张燕霞 王艺峰 吴仲岿 |
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| 作者单位： | 武汉理工大学材料科学与工程学院,湖北武汉,430070;武汉理工大学材料科学与工程学院,湖北武汉430070;武汉大学生物材料与工程研究中心,湖北武汉430070 |
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| 基金项目： | 国家自然科学基金资助项目(20574055)，湖北省杰出青年人材基金(2005ABB020) |
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| 摘 要： | 综述了PEG及其衍生物在生物医用材料表面血液相容性改性中的应用,并介绍了对改性后的表面进行表征的常用方法和手段,如反射红外,水接触角,光电子能谱,表面等离子共振,椭圆偏振仪,蛋白质亲和印迹,蛋白质标记等。
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| 关 键 词： | 生物医用材料 聚乙二醇 表面改性 血液相容性 |
| 文章编号： | 1000-7555（2007）06-0127-05 |
| 修稿时间： | 2006-07-24 |
Blood Compatibility of Biomaterial Surfaces Modified with PEG and Its Derivatives |
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| HU Xiao-yang,CHEN Hong,ZHANG Yan-xia,WANG Yi-feng,WU Zhong-kui. Blood Compatibility of Biomaterial Surfaces Modified with PEG and Its Derivatives[J]. Polymer Materials Science & Engineering, 2007, 23(6): 127-131 |
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| Authors: | HU Xiao-yang CHEN Hong ZHANG Yan-xia WANG Yi-feng WU Zhong-kui |
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| Affiliation: | 1. School of Materials Science and Engineering, Wuhan University Technology, Wuhan 430070, China; 2. Biomedical Materials and Engineering Center, Wuhan University, Wuhan 430070, China |
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| Abstract: | Poly(ethylene glycol)(PEG) and its derivatives are accepted as a kind of ideal polymers to improve surface blood compatibility of biomaterials.Due to their excellent hydrophilicity,mobility,biological inertness,resistance properties of protein adsorption and cell adhesion,PEG and its derivatives are widely used in surface modification of biomaterials.In this article,the applications of PEG and its derivatives in surface modification to improve blood compatibility of biomaterials were reviewed.Some techniques, ATR-FT-IR,Water Contact Angle,X-ray photoelectron spectrometer,Surface Plasmon Resonance,Ellipsometry,Western blot,protein Labeling technology,which are used to characterize PEG-modified biomaterial surfaces,were also introduced in this paper. |
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| Keywords: | biomaterials poly(ethylene glycol) surface modification blood compatibility |
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