Influence of some factors affecting antibacterial activity of PVA/Chitosan based hydrogels synthesized by gamma irradiation |
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| Authors: | Djamel Tahtat Mohamed Mahlous Samah Benamer Assia Nacer Khodja Souad Larbi Youcef Nadjet Hadjarab Wassila Mezaache |
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| Affiliation: | 1.Department of Irradiation Technology,Nuclear Research Center of Algiers,Algiers,Algeria;2.Centre de Recherche Nucléaire d’Alger,Algiers,Algeria;3.University of Science and Technology H. Boumediene,Algiers,Algeria |
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| Abstract: | Poly (vinyl alcohol) hydrogels containing different concentrations of chitosan with molecular weight of 471 and 101 kDa were
crosslinked by gamma irradiation at a dose of 25 kGy. The swelling behavior, gel content and morphological structure of the
blend were investigated. The antibacterial effect, as a function of chitosan content and molecular weight in the hydrogel,
was investigated against Escherichia coli and Bacillus subtilis. With increasing chitosan content the equilibrium degree of swelling of the blend increased and the gel fraction decreased.
Results of antibacterial activity of chitosan revealed that chitosan was more effective in inhibiting growth of gram positive
bacteria than that of gram negative ones. It was observed that, the chitosan content as well as its molecular weight has a
direct influence on bacteria growth inhibition. The higher the chitosan content in the blend and the higher its initial molecular
weight, the larger was the inhibition zone diameter. The bacteria growth inhibition was attributed to the diffusion of entrapped
chitosan from the hydrogel blend to the culture medium. |
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