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| 气相色谱法测定伊潘立酮中丙酮、乙醇等多溶剂残留量 | |
| 引用本文： | 谢艳丽,谭曜,周雪晴,成一,赵振东. 气相色谱法测定伊潘立酮中丙酮、乙醇等多溶剂残留量[J]. 现代仪器, 2012, 18(1): 17-19 |
| 作者姓名： | 谢艳丽 谭曜 周雪晴 成一 赵振东 |
| 作者单位： | 1. 海南省精细化工重点实验室,海口570228;海南大学分析测试中心,海口570228 2. 宁波出入境检验检疫局,宁波,815012 3. 海南大学材料与化工学院,海口,570228 |
| 摘 要： | 目的 :建立毛细管气相色谱法测定伊潘立酮中6种有机残留溶剂的方法。方法 :采用DB-1701(30m×0.32mm×1.0μm)毛细管柱,程序升温:60℃保持1min,然后以6℃/min的升温速率升至83℃,保持8min,再以20℃/min的升温速率升至240℃,保持5min。以DMSO为溶剂,正丁醇为参比物,用校正相对保留时间(RART)定性。结果 :各溶剂能得到较好的分离,精密度、线性关系良好,6种溶剂的平均回收率范围为92.02%~107.83%,RSD值为0.40%~4.56%。结论:本方法简便、准确、灵敏,适合用于伊潘立酮中多种残留溶剂同时测定。 |
| 关 键 词： | 伊潘立酮 气相色谱法 残留溶剂 |
GC determination of 6 kinds of residual solvents in Iloperidone |
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| Xie Yanli , Tan Yao , Zhou Xueqing , Cheng Yi , Zhao Zhendong. GC determination of 6 kinds of residual solvents in Iloperidone[J]. Modern Instruments, 2012, 18(1): 17-19 | |
| Authors: | Xie Yanli Tan Yao Zhou Xueqing Cheng Yi Zhao Zhendong |
| Affiliation: | 1,2(1.Hainan Provincial Key Lab of Fine Chem,Haikou 570228;2.Chemical Analytical and Testing Center of Hainan University,Haikou 570228;3.Ningbo Entry-exit Inspection and Quarantine Bureau of P.R.C,Ningbo 815012;4.Hainan university materials and chemical engineering,Haikou 570228) |
| Abstract: | Objective: To establish a method for determination of the residues of 6 kinds of solvents in Iloperidone by caplillary gas chromatography.Method: The six organic solvents were separated on a DB-1701(30m×0.32mm×1.0μm) using programmable increased temperature.The column temperature is initially maintained at 60℃ for 1 min and then up to 83℃ at the rate of 6 ℃/min for 8 min,and eventually raised to 240℃ at the rate of 20 ℃/min for 5 min.The samples were dissolved in DMSO with 1-butanol as the reference,and the relative adjustment retention time(RART) was applied to manipulate the qualitative analysis.Results: Each solvent was completely separated and excellent linearity and recoveries were obtained.The average recoveries were 92.02% to 107.83% with coefficient of variation from 0.40% to 4.56%.Conclusion: The method is simple,accurate and sensitive.It can be used to determine the residual solvents in Iloperidone. |
| Keywords: | Iloperidone Residual solvent Gas chromatography |
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