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Preparation and application of highly porous aerogel-based bioactive materials in dentistry |
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| Authors: | Andrea Kuttor Melinda Szalóki Tünde Rente Farkas Kerényi József Bakó István Fábián István Lázár Attila Jenei Csaba Hegedüs |
| Affiliation: | 1. Department of Prosthetic Dentistry and Biomaterials, Faculty of Dentistry, University of Debrecen, 4012, Debrecen, Hungary 2. Aerogel Research Group, Department of Inorganic and Analytical Chemistry, Faculty of Science, University of Debrecen, 4010, Debrecen, Hungary 3. Department of Dental Biochemistry, Faculty of Dentistry, University of Debrecen, 4012, Debrecen, Hungary 4. Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, 4012, Debrecen, Hungary |
| Abstract: | In this study, the possibility of preparation and application of highly porous silica aerogel-based bioactive materials are presented. The aerogel was combined with hydroxyapatite and β-tricalcium phosphate as bioactive and osteoinductive agents. The porosity of aerogels was in the mesoporous region with a maximum pore diameter of 7.4 and 12.7 nm for the composite materials. The newly developed bioactive materials were characterized by scanning electron microscopy. The in vitro biological effect of these modified surfaces was also tested on SAOS-2 osteogenic sarcoma cells by confocal laser scanning microscopy. |
| Keywords: | aerogel sol-gel technique bioactive matedal SAOS-2 cell |
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