Measurement and modeling solubility of bioactive coumarin and its derivatives in supercritical carbon dioxide |
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Authors: | Ki-Pung Yoo Hun Yong Shin Min Jeong Noh Seong Sik You |
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Affiliation: | (1) Department of Chemical Engineering, Sogang University, C.P.O. Box 1142, Seoul, Korea |
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Abstract: | To design a supercritical fluid extraction process for the separation of bioactive substances from natural products, a quantitative
knowledge of phase equilibria between target biosolutes and solvent is necessary. How-ever, mostly no such information is
available in literature to date. Thus in the present study, illustratively the solubility of bioactive coumarin and its various
derivatives (i.e., hydroxy-, methyl-, and methoxy-derivatives) in supercritical CO2 were measured at 308.15–328.15 K and 10–30 MPa. Also, the pure physical properties such as normal boiling point, critical
constants, acentric factor, molar volume and standard vapor pressure for coumarin and its derivatives were estimated. By these
estimated information, the measured solubilities were quantitatively correlated by an approximate lattice equation of state
proposed recently by the present authors. |
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Keywords: | Measurement Thermodynamic Modeling Solubility Supercritical Carbon Dioxide Coumarin Derivatives |
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