S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells |
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| Authors: | Laura Mosca Martina Pagano Annalisa Pecoraro Luigi Borzacchiello Luigi Mele Giovanna Cacciapuoti Marina Porcelli Giulia Russo Annapina Russo |
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| Affiliation: | 1.Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio, 80138 Naples, Italy; (L.M.); (L.B.); (G.C.);2.Department of Pharmacy, University of Naples “Federico II”, Via Domenico Montesano 49, 80131 Naples, Italy; (M.P.); (A.P.);3.Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via Luciano Armanni, 5, 80138 Naples, Italy; |
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| Abstract: | Purpose: In order to study novel therapeutic approaches taking advantage of natural compounds showing anticancer and anti-proliferative effects, we focused our interest on S-adenosyl-l-methionine, a naturally occurring sulfur-containing nucleoside synthesized from adenosine triphosphate and methionine by methionine adenosyltransferase, and its potential in overcoming drug resistance in colon cancer cells devoid of p53. Results: In the present study, we demonstrated that S-adenosyl-l-methionine overcomes uL3-mediated drug resistance in p53 deleted colon cancer cells. In particular, we demonstrated that S-adenosyl-l-methionine causes cell cycle arrest at the S phase; inhibits autophagy; augments reactive oxygen species; and induces apoptosis in these cancer cells. Conclusions: Results reported in this paper led us to propose S-adenosyl-l-methionine as a potential promising agent for cancer therapy by examining p53 and uL3 profiles in tumors to yield a better clinical outcomes. |
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| Keywords: | uL3 drug resistance AdoMet autophagy apoptosis colon cancer |
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