Nanoheterojunction Engineering Enables NIR-II-Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor-Synergistic Therapy |
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Authors: | Shan Zhang Lina Wu Wenqiang Shi Junchang Qin Wei Feng Yu Chen Ruifang Zhang |
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Affiliation: | 1. Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 P. R. China;2. Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444 P. R. China;3. Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 P. R. China |
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Abstract: | Photodynamic therapy (PDT) as a non-invasive strategy shows high promise in cancer treatment. However, owing to the hypoxic tumor microenvironment and light irradiation-mediated rapid electron–hole pair recombination, the therapeutic efficacy of PDT is dramatically discounted by limited reactive oxygen species (ROS) generation. Herein, a multifunctional theranostic nanoheterojunction is rationally developed, in which 2D niobium carbide (Nb2C) MXene is in situ grown with barium titanate (BTO) to generate a robust photo-pyroelectric catalyst, termed as BTO@Nb2C nanosheets, for enhanced ROS production, originating from the effective electron–hole pair separation induced by the pyroelectric effect. Under the second near-infrared (NIR-II) laser irradiation, Nb2C MXene core-mediated photonic hyperthermia regulates temperature variation around BTO shells facilitating the electron–hole spatial separation, which reacts with the surrounding O2 and H2O molecules to yield toxic ROS, achieving a synergetic effect by means of combinaterial photothermal therapy with pyrocatalytic therapy. Correspondingly, the engineered BTO@Nb2C composite nanosheets feature benign biocompatibility and high antitumor efficiency with the tumor-inhibition rate of 94.9% in vivo, which can be applied as an imaging-guided real-time non-invasive synergetic dual-mode therapeutic nanomedicine for efficient tumor nanotherapy. |
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Keywords: | nanoheterojunctions photonic hyperthermia pyrocatalytic therapy ROS generation |
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