3D Hollow Porous Radio-Granular Hydrogels for SPECT Imaging-Guided Cancer Intravascular Brachytherapy |
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Authors: | Xiao Xu Hu Chen Pan He Zhenwen Zhao Xing Gao Chao Liu Hongwei Cheng Lai Jiang Peiyu Wang Yang Zhang Xiaofei Wen Yesen Li Jinxiong Huang Yongfu Xiong Jingsong Mao Hongjuan Ma Gang Liu |
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Affiliation: | 1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102 China;2. Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003 China;3. Shanghai Applied Radiation Institute, Shanghai University, Shanghai, 200444 China |
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Abstract: | Radioactive microspheres have shown excellent therapeutic effects in the treatment of advanced hepatocellular carcinoma (HCC) due to indiscriminate embolization and killing of tumor cells. However, limitations such as unstable loading, in vivo reflux, and untrackable radioactive microspheres restrict their clinical applicability. Herein, a novel injectable lutetium-177-labeled 3D hollow porous radio-granular hydrogels with a double-cross-linked network (177Lu-3D-HPGH) are synthesized via microfluidics combined with ultraviolet photo-cross-linking technology is reported. The radiolabeling efficiency of 177Lu-3D-HPGH can reach 97.85%. The 3D hollow porous radio-granular hydrogels exhibited uniform, controllable size, radio-theranostics, and excellent underwater adhesion properties, avoiding unwanted radiation damage to non-target organs. Particularly, the extended X-ray absorption fine structure combined with the density functional theory calculation revealed the mechanism of 3D-HPGH loading with 177Lu through Lu-N/O coordination. Furthermore, rabbit orthotopic kidney and liver tumor models are used to verify the excellent embolization performance, radionuclide loading stability, anti-reflux characteristics, anti-tumor effect, and biosafety of 177Lu-3D-HPGH. Briefly, this facile, green, and safe synthesis strategy provides a superior choice for intravascular brachytherapy of HCC and has great application value and transformative potential in clinical diagnosis and treatment. |
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Keywords: | 3D hollow porous radio-granular hydrogels hepatocellular carcinoma lutetium-177 radioactive microspheres |
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