Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles |
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| Authors: | Asit Kumar Lina Zhou Kaining Zhi Babatunde Raji Shelby Pernell Erene Tadrous Sunitha Kodidela Anantha Nookala Harry Kochat Santosh Kumar |
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| Affiliation: | 1.Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA; (L.Z.); (S.P.); (E.T.); (S.K.);2.Plough Center for Sterile Drug Delivery Solutions, University of Tennessee Health Science Center, Memphis, TN 38104, USA; (K.Z.); (B.R.); (H.K.);3.Covance Inc., Kinsman Blvd, Madison, WI 53704, USA; |
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| Abstract: | Biomaterials have been the subject of numerous studies to pursue potential therapeutic interventions for a wide variety of disorders and diseases. The physical and chemical properties of various materials have been explored to develop natural, synthetic, or semi-synthetic materials with distinct advantages for use as drug delivery systems for the central nervous system (CNS) and non-CNS diseases. In this review, an overview of popular biomaterials as drug delivery systems for neurogenerative diseases is provided, balancing the potential and challenges associated with the CNS drug delivery. As an effective drug delivery system, desired properties of biomaterials are discussed, addressing the persistent challenges such as targeted drug delivery, stimuli responsiveness, and controlled drug release in vivo. Finally, we discuss the prospects and limitations of incorporating extracellular vesicles (EVs) as a drug delivery system and their use for biocompatible, stable, and targeted delivery with limited immunogenicity, as well as their ability to be delivered via a non-invasive approach for the treatment of neurodegenerative diseases. |
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| Keywords: | drug delivery drug loading biomaterial extracellular vesicles exosomes microvesicles/microparticles neurodegenerative disease |
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