Multifunctional Silver Nanoparticles-Decorated Silica Functionalized with Retinoic Acid with Anti-Proliferative and Antimicrobial Properties |
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| Authors: | Madalina Tudose Daniela C. Culita Adina M. Musuc Gabriela Marinescu Simona Somacescu Cornel Munteanu Coralia Bleotu Mariana C. Chifiriuc |
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| Affiliation: | 1.Institute of Physical Chemistry “Ilie Murgulescu”,Romanian Academy,Bucharest,Romania;2.St. S. Nicolau Virology Institute,Bucharest,Romania;3.Microbiology Immunology Department, Faculty of Biology,University of Bucharest,Bucharest,Romania;4.Research Institute of the University of Bucharest,Bucharest,Romania |
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| Abstract: | The paper describes a rapid and simple method for preparing a multifunctional biomaterial based on retinoic acid covalently bound on silica@Ag particles. Monodispersed SiO2 particles were prepared by Stöber method and further used for loading the Ag nanoparticles on their surface. This composite was further functionalized with retinoic acid. Characterization of the hybrid materials was made by UV–Visible spectroscopy, Transmission electron microscopy, Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and Thermal analysis. The biological evaluation of the obtained materials revealed their potential use for multiple biomedical applications, from anti-proliferative agents to novel antimicrobial and antibiofilm strategies. |
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