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人体内DTPA的排出及其对~(241)Am排泄量的影响
引用本文:贾国纲,吕颖,白光,余耀仙.人体内DTPA的排出及其对~(241)Am排泄量的影响[J].辐射防护,1988(1).
作者姓名:贾国纲  吕颖  白光  余耀仙
作者单位:中国原子能科学研究院 (贾国纲,吕颖,白光),中国原子能科学研究院(余耀仙)
摘    要:本文报道给人肌肉注射或雾化吸入 DTPA 后尿中 DTPA 的排出情况。观察结果表明,两种给药方式尿中 DTPA 的排出分数均可用两个指数项之和来描述。肌肉注射给药时,快排部分约占注入量的97%,半减期为88min;慢排部分约占3%,半减期为292min。雾化吸入给药后,快排部分约占81%,半减期为92min;慢排部分约占19%,半减期为624min。DTPA 对~(241)Am 的促排效果是明显的,本实验条件下平均促排倍数大于18。

关 键 词:DOPA  排泄  人体  ~(241)Am  尿

EXCRETION OF DTPA FROM HUMAN BODY AND THE EFFECT OF DTPA ON THE EXCRETION OF ~(241)Am IN URINE
Jia Guogang,Lu Ying,Bai Guang,Yu Yaoxian.EXCRETION OF DTPA FROM HUMAN BODY AND THE EFFECT OF DTPA ON THE EXCRETION OF ~(241)Am IN URINE[J].Radiation Protection,1988(1).
Authors:Jia Guogang  Lu Ying  Bai Guang  Yu Yaoxian
Affiliation:Institute of Atomic Energy
Abstract:In this paper,the excretion of DTPA in urine was studiedafter intramuscular injection or inhalation as an aerosol.For two admi-nistration of DTPA,the excretion fraction of DTPA in urine can bedescribed by sum of two exponent functions.For intramuscular injection,the fast removal part is about 97% of all the activity administered with ahalf-life of 88 minutes;the slow removal part is about 3% with a half-life of 292 minutes;the excretion rate of DTPA within 24 hours is about99%.For inhalation of DTPA,the fast removal part is about 81% witha half-life of 92 minutes;the slow removal part is about 19% with a half-life of 624 minutes.The therapeutic effect of DTPA on ~(241)Am is good,the average excretion of ~(241)Am in urine after treatment is 18 times morethan that before treatment.
Keywords:DTPA  Excretiop  Human Body  ~(214)Am  Urine  
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