| 动态光谱和PLS在人体血液红细胞无创测量中的应用 |
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| 引用本文： | 贾萍,张宝菊,张志勇,林凌,门剑龙,李刚. 动态光谱和PLS在人体血液红细胞无创测量中的应用[J]. 红外与毫米波学报, 2010, 29(2): 132-135 |
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| 作者姓名： | 贾萍 张宝菊 张志勇 林凌 门剑龙 李刚 |
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| 作者单位： | 天津师范大学,物理与电子信息学院,天津,300387;天津大学,天津市生物医学检测技术与仪器重点实验室,天津,300072;天津农学院,机电工程系,天津,300384;天津大学,天津市生物医学检测技术与仪器重点实验室,天津,300072;天津大学,天津市生物医学检测技术与仪器重点实验室,天津,300072;天津医科大学总医院,天津,300052 |
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| 基金项目： | 国家自然科学基金资助项目(No.60174032,60674111) |
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| 摘 要： | 首次利用动态光谱指端透射法进行了人体红细胞无创测量的研究.对28名健康志愿者进行了在体测量,选用偏最小二乘法(PLS)对获取的动态光谱数据和红细胞实测值进行建模分析,得到定标集和验证集的相关系数分别为0.9193和0.9058,验证集的相对误差最大为7.96%,平均相对误差为6.21%.结果表明,动态光谱法可以有效地克服个体差异等对光谱测量的影响,较准确地进行人体红细胞含量的测量,是一种比较好的血液成分无创测量方法.
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| 关 键 词： | 动态光谱 红细胞 无创测量 偏最小二乘法 |
| 收稿时间： | 2009-03-08 |
| 修稿时间： | 2009-09-21 |
APPLICATION OF DYNAMIC SPECTRUM AND PARTIAL LEAST-SQUARES IN NONINVASIVE MEASUREMENT OF HUMAN ERYTHROCYTE CONTENT |
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| JIA Ping,ZHANG Bao-Ju,ZHANG Zhi-Yong,LIN Ling,MEN Jian-Long and LI Gang. APPLICATION OF DYNAMIC SPECTRUM AND PARTIAL LEAST-SQUARES IN NONINVASIVE MEASUREMENT OF HUMAN ERYTHROCYTE CONTENT[J]. Journal of Infrared and Millimeter Waves, 2010, 29(2): 132-135 |
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| Authors: | JIA Ping ZHANG Bao-Ju ZHANG Zhi-Yong LIN Ling MEN Jian-Long LI Gang |
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| Affiliation: | 1.College of Physics & Electronic Information;Tianjin Normal University;Tianjin 300387;China;2.Tianjin Key Laboratory of Biomedical Detection & Instruments;Tianjin University;Tianjin 300072;3.Department of Electromechanical Engineering;Tianjin Agricultural College;Tianjin 300384;4.Clinical Laboratory Devision General Hospital of Tianjin Medical University;Tianjin 300052;China |
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| Abstract: | Dynamic spectrum (DS) method was used to measure non-invasively human erythrocyte content for the first time.In vivo measurements were carried out to 28 healthy volunteers,and parital least-squares(PLS) regression was used to establish the calibration model of subjects' erythrocyte content values against DS data.The correlation coefficients were 0.9193 and 0.9058 for calibration set and validation set,respectively.The biggest relative error of validation is 7.96%,and the average relative error is 6.21%.Measurement results show that the influences of individual differences on spectra can be decreased effectively by DS method.This method can measure accurately human erythrocyte content and it is a promising method for non-invasive blood analysis. |
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| Keywords: | Dynamic Spectrum(DS) Erythrocyte Non-invasive Measurement Parital Least-Squares(PLS) |
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