Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases |
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Authors: | Piaoyang Liu Shun Li Liling Tang |
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Affiliation: | 1.Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China;2.Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu 610500, China;3.Non-Coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu 610500, China |
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Abstract: | The lungs play a very important role in the human respiratory system. However, many factors can destroy the structure of the lung, causing several lung diseases and, often, serious damage to people’s health. Nerve growth factor (NGF) is a polypeptide which is widely expressed in lung tissues. Under different microenvironments, NGF participates in the occurrence and development of lung diseases by changing protein expression levels and mediating cell function. In this review, we summarize the functions of NGF as well as some potential underlying mechanisms in pulmonary fibrosis (PF), coronavirus disease 2019 (COVID-19), pulmonary hypertension (PH), asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Furthermore, we highlight that anti-NGF may be used in future therapeutic strategies. |
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Keywords: | nerve growth factor lung coronavirus disease 2019 pathway |
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