Postnatal changes in activation of polyunsaturated fatty acid,acylation of lysophosphoglyceride,and phosphorylation of diacylglycerol in cortical gray matter of rat cerebrum |
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Authors: | Ayako Kanazawa Yukari Watanabe Kenshiro Fujimoto |
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Affiliation: | (1) Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, 981 Sendai, Japan |
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Abstract: | Activation of polyunsaturated fatty acid, acylation of lysophosphoglyceride, and phosphorylation of diacylglycerol in postnatal
developing rat cerebrum were studiedin vitro, using cortical gray matter homogenates. The rate of n-3 and n-6 fatty acid activation was maximal at ten days after birth
and minimal at adulthood. Acylation of lysophosphoglyceride was most active at the neonatal stage and gradually decreased
with age. In addition, the amount of phosphatidic acid formed from 1, 2-dioleoyl-glycerol was also maximum at the neonatal
stage, and then gradually decreased. These results suggest that the specific activity of glycerolipid synthesis in cortical
gray matter declines during postnatal development. |
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