Synthesis, characterization and high in vitro antitumour activity of novel triphenyltin carboxylates |
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Authors: | Gielen M El Khloufi A Biesemans M Bouhdid A de Vos D Mahieu B Willem R |
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Affiliation: | Free University of Brussels (V.U.B.) Pleinlaan 2 Faculty of Applied Sciences Laboratory for General and Organic Chemistry (AOSC), Room 8G512 Brussels B-1050 Belgium. |
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Abstract: | The synthesis and spectral characterization of six novel triphenyltin compounds are described. The in vitro antitumour activity of three of these compounds against two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, was determined. All three compounds are more active than cis-platin, etoposide and doxorubicin against both tumour cell lines. They are as active as mitomycin C against WiDr, but less active against MCF-7. |
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