大豆异黄酮防治前列腺癌的研究进展

大豆异黄酮是广泛分布于豆荚类植物中的黄酮类化合物。流行病学研究表明大豆异黄酮对前列腺癌具有防治作用,该功能与大豆异黄酮能诱导前列腺癌细胞细胞凋亡、抑制生长增殖,增强放疗、化疗的功效,调节DNA损伤修复及DNA甲基化,拮抗雄激素介导的信号通路等有关。本文就近年来大豆异黄酮对前列腺癌的防治作用及机制作一综述。 

Research progress in soy isoflavones on prostate cancer and the underlying mechanism

Soy isoflavone belongs to flavonoids and widely distributed in the bean pods plants. Epidemiological studies have shown that soy isoflavones can exert the function of anti- prostate cancer,which is related to inducing apoptosis and inhibiting growth proliferation of PCa cells,enhancing radio and chemotherapeutic agents,regulating of DNA repair and methylation and antagonism of androgen- mediated signaling pathways. In this paper,the research of soy isoflavones against prostate cancer and the underlying mechanism was summarized.