玫瑰红景天提取物rosavin抗疲劳作用的实验研究

目的:研究玫瑰红景天提取物rosavin对小鼠的抗疲劳作用。方法:实验分为对照组、rosavin低、中、高剂量组(60,180,360mg/kgmb)以及红景天苷阳性对照组(180mg/kgmb),对照组灌胃生理盐水,连续灌胃30d。分别测定小鼠力竭游泳时间,运动后肌乳酸、肝糖原、肌糖原和血清尿素氮含量。结果:与对照组比较,rosavin组的高、中、低剂量组均能延长小鼠力竭游泳时间(p<0.05),运动后肝糖原(p<0.05)、肌糖原含量高于对照组小鼠,肌乳酸浓度明显低于对照组(p<0.05)。与红景天苷阳性对照组比较,同等剂量下红景天苷抗疲劳效果略优于rosavin,rosavin高剂量组与红景天苷抗疲劳效果相当,两者差异没有显著性(p>0.05)。结论:rosavin有缓解体力疲劳的作用。 

Anti-fatigue effects of rosavin extracted from Rhodiola rosea L.

Objective:To study the anti-fatigue effects of rosavin extracted from Rhodiola rosea L. in mice. Methods:The mice were randomly divided into five groups including the control group administered with physiological saline, three rosavin groups administered with doses of 60, 180, 360mg/kg mb rosavin and salidroside group (180mg/kg mb) for 30 consecutive days, respectively. And the level of muscle lactate, liver and muscle glycogen, serum urea nitrogen and the exhaustive swimming time were determined after swimming test. Results:Compared with control group, different doses of rosavin significantly extended the swimming time (p<0.05) and increased the contents of liver (p<0.05) and muscle glycogen, while reducing that of lactate in muscle significantly (p<0.05) . Salidroside was slightly better than rosavin in the anti-fatigue effects of the same dose. But there was no significant difference in rosavin and salidroside (p>0.05) . Conclusion:rosavin had anti-fatigue effect on mice.