富自体浓缩生长因子生物学作用的研究进展

富自体浓缩生长因子(concentrated growth factor,CGF)为第三代血小板浓缩产物,是再生医疗领域中诱导组织再生分化的一种新型生物材料。CGF通过差速离心可释放出多种生长因子,如血小板衍生生长因子(plateletderived growth factor,PDGF)、转化生长因子-β(transforming growth factor-β,TGF-β)、类胰岛素生长因子(insulin-like growth factor,IGF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、表皮生长因子(epidermal growth fcator,EGF)及成纤维细胞生长因子(fibroblast growth factor,FGF)等,这些生长因子相互作用,可发挥促进组织再生的作用。本文就CGF在促进细胞增殖及分化、组织再生及修复、软组织愈合等生物学作用中的研究进展作一综述。

Progress in research on biological function of autologous concentrated growth factor

As the third-generation of platelet concentrate,autologous concentrated growth factor(CGF)is novel biomaterial which induces tissue regeneration and differentiation in the field of regenerative medicine.Autologous CGF releases a variety of growth factors such as platelet-derived growth factor(PDGF),transforming growth factor-β(TGF-β),insulin-like growth factor(IGF),vascular endothelial growth factor(VEGF),epidermal growth factor(EGF)and fibroblast growth factor(FGF)by differential centrifugation.These growth factors interact to play a role in promoting tissue regeneration.In this paper,the progress in research on the biological function of autologous CGF in promoting the cell proliferation and differentiation,tissue regeneration and repair and soft tissue healing are reviewed.