| 人尿中环丁甲羟氢吗啡及其代谢物的GC／MS分析研究 |
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| 引用本文： | 申利 徐友宣. 人尿中环丁甲羟氢吗啡及其代谢物的GC／MS分析研究[J]. 质谱学报, 1995, 16(3): 27-30 |
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| 作者姓名： | 申利 徐友宣 |
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| 作者单位： | 国家体委运动医学研究所兴奋剂检测中心 |
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| 摘 要： | 环丁尿羟氢啡阳性尿经酶解、醚洗、乙酸乙酯－异丙醇提取、衍生化后，用ＧＣ／ＭＳＤ进行分析，检出了环丁甲羟氢吗啡及其１种代谢物，方法灵敏简便。
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| 关 键 词： | 环丁甲羟氢吗啡 气相色谱 质谱 尿液检验 运动员 |
Analysis of Nalbuphine and Its Metabolite in Human Urine by GC/MS |
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| Shen Li, Xu Youxuan,Wu Yun,Wang Shan,Zhang Changjiu. Analysis of Nalbuphine and Its Metabolite in Human Urine by GC/MS[J]. Journal of Chinese Mass Spectrometry Society, 1995, 16(3): 27-30 |
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| Authors: | Shen Li Xu Youxuan Wu Yun Wang Shan Zhang Changjiu |
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| Abstract: | A GC/MS method for the analysis of nalbuphine and its major metabolite is described. The urine sample was acid hydrolyzed,cleaned with diethyl ether,extracted with ethyl acetate/isopropanol,and derivazed with MSTFA-MBTFA. Nalbuphine and one of its metabolites were detected in urine sample within 1-36 h after administration of the drug. The method is fast and sensitive. |
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| Keywords: | nalbuphine metabolite GC/MS |
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