| 神经生长因子在小鼠体内的分布与排泄实验研究 |
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| 引用本文： | 姜国辉 陈力真. 神经生长因子在小鼠体内的分布与排泄实验研究[J]. 核技术, 1998, 21(11): 649-652 |
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| 作者姓名： | 姜国辉 陈力真 |
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| 作者单位： | 中国医学科学院中国协和医科大学北京协和医院!北京，100730，中国医学科学院中国协和医科大学北京协和医院!北京，100730，中国医学科学院中国协和医科大学基础医学研究所!北京，100730，中国医学科学院中国协和医科大学基础医学研究所!北京，100730，中国医学科学院中国协和医科 |
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| 摘 要： | 采用氯胺－Ｔ法对神经生长因子（Ｎｅｒｖｒｅｇｒｏｗｔｈｆａｃｔｏｒ，ＮＧＦ）进行碘标记，研究了ＮＧＦ在小鼠体内的分布与排泄规律，结果表明，ＮＧＦ在小鼠体内组织器官的分布速率以及颈上神经节，甲状腺，胆囊，肾脏，肾上腺等组织较快，各器官的达峰时间为２０－３０ｍｉｎ，肌注＾１２５Ｉ－ＮＧＦ７２ｈ内，小鼠粪尿中放射性排泄总量达７２．５５％，其中尿内累积量约占排泄总量的６５．６４％，而粪便中只占不足７％。
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| 关 键 词： | 神经生长因子 排泄 体内分布 碘125 碘标记 |
The distribution and excretion of nerve growth factor in mice |
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| JIANG Guohui,TANG Ganghua,CHEN Lizhen,ZHANG Yun,WANG Shizhen. The distribution and excretion of nerve growth factor in mice[J]. Nuclear Techniques, 1998, 21(11): 649-652 |
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| Authors: | JIANG Guohui TANG Ganghua CHEN Lizhen ZHANG Yun WANG Shizhen |
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| Abstract: | Nerve growth factor(NGF) was iodolabelled with chloramine-T method and its distribution and excretion in mice were investigated. The results showed that the highest levels were found in superior cervical ganglia, thyroid, bile, kidneys and adrenals between 20-30 min after injection, and the peak time in most tissues was also found at 20-30 min. About 72.55% of the injected dose was excreted in stool and urine, among them 65.6% was excreted in urine and only 7.0% in stool within 72h after intramuscular injection. |
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| Keywords: | Nerve growth factor(NGF) (125)~I labelled Distribution Excretion |
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