Magnetically responsive,sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment |
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| Authors: | ükran Alpdemir Tayfun Vural Gknur Kara Cem Bayram Erdem Haberal Emir Baki Denkba |
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| Affiliation: | 1. Bioengineering Division, Hacettepe University, Beytepe Ankara, Turkey ; 2. International Cooperation Unit of TUBITAK, Kavaklidere Ankara, Turkey ; 3. Chemistry Department, Hacettepe University, Beytepe Ankara, Turkey ; 4. Chemistry Department, Biochemistry Division, Ordu University, Ordu Turkey ; 5. Department of Nanotechnology and Nanomedicine, Hacettepe University, Beytepe Ankara, Turkey ; 6. Biomedical Engineering Department, Baskent University, Baglica Ankara, Turkey |
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| Abstract: | This study aimed to develop sorafenib loaded magnetic microspheres for the treatment of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised and encapsulated in alginate microspheres together with an antineoplastic agent, sorafenib. In the study, firstly SPIONs were synthesised and characterised by dynamic light scattering, energy‐dispersive X‐ray spectroscopy, and scanning electron microscopy. Then, alginate‐SPIONs microspheres were developed, and further characterised by electron spin resonance spectrometer and vibrating sample magnetometer. Besides the magnetic properties of SPIONs, alginate microspheres with SPIONs were also found to have magnetic properties. The potential use of microspheres in hyperthermia treatment was then investigated and an increase of about 4°C in the environment was found out. Drug release studies and cytotoxicity tests were performed after sorafenib was encapsulated into the magnetic microspheres. According to release studies, sorafenib has been released from microspheres for 8 h. Cytotoxicity tests showed that alginate‐SPION‐sorafenib microspheres were highly effective against cancerous cells and promising for cancer therapy.Inspec keywords: drug delivery systems, drugs, nanofabrication, magnetic particles, iron compounds, scanning electron microscopy, hyperthermia, biomedical materials, encapsulation, nanoparticles, light scattering, nanomagnetics, cellular biophysics, toxicology, cancer, nanomedicine, superparamagnetism, nanocomposites, magnetometry, paramagnetic resonance, X‐ray chemical analysisOther keywords: sorafenib loaded alginate microspheres, hepatocellular carcinoma treatment, sorafenib loaded magnetic microspheres, superparamagnetic iron oxide nanoparticles, dynamic light scattering, energy‐dispersive X‐ray spectroscopy, scanning electron microscopy, electron spin resonance spectrometer, vibrating sample magnetometer, hyperthermia treatment, drug release, alginate‐SPION‐sorafenib microspheres, antineoplastic agent, cytotoxicity tests, cancerous cells, time 8.0 hour, Fe3 O4 |
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