Synthesis of porous GdF3 :Er3+, Yb3+ –COOH core–shell structured bi‐functional nanoparticles for drug delivery

The authors synthesised porous GdF₃ :Er³⁺, Yb³⁺ –COOH core–shell structured bi‐functional nanoparticles through a one‐step hydrothermal route during which ethylene diamine tetraacetic acid) was bound to the surface of the nanoparticles. It has high up‐conversion emission intensity for monitoring the drug release process and magnetisation saturation value (10.2 emu/g) for drug targeting under foreign magnetic fields. Moreover, porous GdF₃ :Er³⁺, Yb³⁺ as drug carriers with a high drug‐loading efficiency. cis‐Dichlorodiammineplatinum(II) (cisplatin, CDDP)‐loaded GdF₃ :Er³⁺, Yb³⁺ nanoparticles (GdF₃ :Er³⁺, Yb³⁺ –CDDP) were characterised by the Fourier transform infrared spectra, and CDDP was loaded in the form of electrostatic interaction and hydrogen bonds. Compared with CDDP alone, GdF₃ :Er³⁺, Yb³⁺ –CDDP nanoparticles increase concentration of CDDP in the target site and enhance its anticancer efficiency. Therefore, the as‐prepared GdF₃ :Er³⁺, Yb³⁺ –COOH nanoparticles allow simultaneous targeted drug delivery and monitoring as promising anti‐cancer theranostic agents.Inspec keywords: gadolinium compounds, erbium, ytterbium, organic compounds, nanoporous materials, core‐shell nanostructures, drug delivery systems, Fourier transform infrared spectra, electrostatics, hydrogen bonds, magnetisation, nanofabrication, nanomedicine, spectrochemical analysisOther keywords: porous core–shell structured bifunctional nanoparticles, drug delivery, one‐step hydrothermal route, ethylene diamine tetraacetic acid, magnetisation saturation value, up‐conversion emission intensity, cis‐Dichlorodiammineplatinum(II), Fourier transform infrared spectra, electrostatic interaction, hydrogen bonds, anticancer theranostic agents