Effect of GNP functionalisation and multiple N ‐methylation of β ‐amyloid residue (32–37) on Gram‐positive bacterium

In the previous report, the authors showed the gold nanoparticle (GNP) functionalised multiple N ‐methylated fragments of the residue (32–37) of beta (β)‐amyloid protein (1–42), CGGIGLMVG and CGGGGGIGLMVG toward disruption of β ‐amyloid (1–42), the predominant component of senile plaques. Herein the in vitro antimicrobial activities of both normal and multiple N ‐methylated sequences of CGGIGLMVG and CGGGGGIGLMVG were screened and it was found that all the eight sequences including four (non‐functionalised with GNP) to possess activity against both Gram‐positive Staphylococcus aureus (ATCC 43300) and Enterococcus faecalis (ATCC 5129)] and Gram‐negative Escherichia coli (ATCC 35218), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 700603)] bacteria. Among them, N ‐methylated sequences CGGIGLMVG and CGGGGGIGLMVG shown remarkable activity against Gram‐positive bacteria.Inspec keywords: microorganisms, gold, nanoparticles, nanomedicineOther keywords: GNP functionalisation, N‐methylation, β‐amyloid residue, Gram‐positive bacterium, gold nanoparticle functionalised multiple N‐methylated fragments, beta β‐amyloid protein, CGGGGGIGLMVG, Staphylococcus aureus, ATCC 43300, Enterococcus faecalis, ATCC 5129, Escherichia coli, ATCC 35218, Pseudomonas aeruginosa, ATCC 27853, Klebsiella pneumoniae, ATCC 700603, Au