Electrospun polyurethane and soy protein nanofibres for wound dressing applications |
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| Authors: | Nithya Sampath Kumar Chella Santhosh Shruthi Vathaluru Sudakaran Ananya Deb Vimala Raghavan Velmurugan Venugopal Amit Bhatnagar Savithri Bhat Nirmala Grace Andrews |
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| Affiliation: | 1. Centre for Nanotechnology Research, VIT University, Vellore Tamil Nadu, 632014 India ; 2. Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, FI‐70211 Kuopio Finland ; 3. Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore Tamil Nadu, 632014 India ; 4. Department of Biotechnology, BMS College of Engineering, Bangalore Karnataka, India |
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| Abstract: | In this report, a novel wound dressing material has been woven by electrospinning technique and tested for its various properties. For the nanofibre mat, a mixture of polyurethane (PU) and soy protein isolate (SPI) was electrospun in conjugation with zinc oxide nanoparticles (ZnO Nps) and ciprofloxacin hydrochloride (CipHCl) to produce fibrous mats viz. PU/SPI/ZnO and PU/SPI/CipHCl. An optimum ratio (1 : 1) of PU/SPI was used as suitable polymeric ratio in order to produce homogenous nanofibres without beads having an average diameter in the range of 300–350 nm. The electrospun nanofibre‐based mats were characterised using X‐ray diffraction, Fourier transform infrared spectroscopy, ultraviolet‐visible spectroscopy, thermogravimetric analysis and scanning electron microscope. The mechanical properties of the nanofibrous mats were tested using universal testing machine. The wettability analysis was done using the contact angle measurement based on the sessile drop test. This study revealed that the electrospun PU/SPI‐based nanofibres are non‐sensitizing, non‐allergic and non‐toxic and that it can be used as a peculiar wound healing material.Inspec keywords: polymer fibres, nanofibres, nanomedicine, biomedical materials, wounds, electrospinning, zinc compounds, II‐VI semiconductors, wide band gap semiconductors, nanoparticles, nanofabrication, X‐ray diffraction, Fourier transform spectra, infrared spectra, ultraviolet spectra, visible spectra, thermal analysis, scanning electron microscopy, wetting, contact angle, toxicologyOther keywords: electrospun polyurethane nanofibres, soy protein nanofibres, wound dressing applications, electrospinning, nanofibre mat, soy protein isolate, zinc oxide nanoparticles, ciprofloxacin hydrochloride, X‐ray diffraction, Fourier transform infrared spectroscopy, ultraviolet‐visible spectroscopy, thermogravimetric analysis, scanning electron microscope, mechanical properties, universal testing machine, wettability, contact angle measurement, sessile drop test, nonsensitizing nanofibres, nonallergic nanofibres, nontoxic nanofibres, wound healing material, wavelength 300 nm to 350 nm, ZnO |
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