Design and development of artemisinin and dexamethasone loaded topical nanodispersion for the effective treatment of age‐related macular degeneration |
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| Authors: | Chandrasekar Ponnusamy Abimanyu Sugumaran Venkateshwaran Krishnaswami Ruckmani Kandasamy Subramanian Natesan |
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| Affiliation: | 1. Department of Pharmaceutical Technology, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli Tamilnadu, India ; 2. Department of Pharmaceutics, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur Tamilnadu, India |
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| Abstract: | Age‐related macular degeneration (AMD) is a disease affecting the macula by the new blood vessels formation. AMD is widely treated with a combination of anti‐angiogenic and anti‐vascular endothelial growth factor (VEGF) agents. The topical administration of nanodispersions showed enhanced ocular residence time with controlled and prolonged drug delivery to the disease site at the back of the eye. In the present study we developed and characterized nanodispersion containing anti‐angiogenic (artemisinin) and anti‐VEGF agent (dexamethasone) for the topical ocular administration in order to obtain a required drug concentration in the posterior part of the eye. The nanodispersions were prepared with varying concentration of polymer, polyvinyl pyrrolidone K90 and polymeric surfactant, Poloxamer 407. The nanodispersions were found to be smooth and spherical in shape with a size range of 12–26 nm. In‐vitro drug release studies showed the 90–101% of artemisinin and 55–103% of dexamethasone release from the nanodispersions. The blank formulation with a high concentration of polymer and polymeric surfactant showed an acceptable level of haemolysis and DNA damage. The chorioallantoic membrane assay suggested that the nanodispersion possess good anti‐angiogenic effect. Hence the formulated artemisinin and dexamethasone nanodispersion may have the great potential for the AMD treatment.Inspec keywords: drug delivery systems, drugs, eye, blood vessels, DNA, biochemistry, nanofabrication, molecular biophysics, nanomedicine, diseases, biomedical materials, polymers, membranesOther keywords: topical administration, enhanced ocular residence time, controlled prolonged drug delivery, disease site, eye, topical ocular administration, polymeric surfactant, dexamethasone release, dexamethasone nanodispersion, AMD treatment, blood vessel formation, drug concentration, in‐vitro drug release, antiangiogenic effect, artemisinin, dexamethasone loaded topical nanodispersion, age‐related macular degeneration effective treatment, antivascular endothelial growth factor agents, antiangiogenic endothelial growth factor agents, antiVEGF agent, polyvinyl pyrrolidone K90, polymer concentration, Poloxamer 407, size 12.0 nm to 26.0 nm, chorioallantoic membrane assay, DNA damage, haemolysis |
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