HSA loaded with CoFe2 O4 /MNPs as a high‐efficiency carrier for epirubicin anticancer drug delivery |
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| Authors: | Fatemeh Karimi Abdollah Fallah Shojaei Khalil Tabatabaeian Hassan Karimi&#x;Maleh Shahryar Shakeri |
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| Affiliation: | 1. Department of Chemistry, University Campus 2, University of Guilan, Rasht Iran ; 2. Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 1914, Rasht Iran ; 3. Department of Chemical Engineering, Laboratory of Nanotechnology, Quchan University of Technology, Quchan Iran ; 4. Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman Iran |
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| Abstract: | Drug delivery is one of the most important challenges in the domain of health. Non‐toxic and biocompatible carriers are provided by human serum albumin nano‐capsule (HSA/NC) for drug delivery applications. In this study, HSA, with high loadings of drug‐modified cobalt ferrite (CoFe2 O4) magnetic nanoparticle (CoFe2 O4 /MNPs) was fabricated for epirubicin anticancer drug delivery. In the initial step, CoFe2 O4 /MNPs was synthesised via co‐precipitation technique and characterised by X‐ray powder diffraction, vibrating sample magnetometry, energy dispersive X‐ray analysis, scanning electron microscopy and map analysis. Furthermore, CoFe2 O4 /MNPs and epirubicin were loaded into HSA/NC and utilised as a novel system against breast cancer cell line (MCF‐7). IC50 for free epirubicin, unloaded CoFe2 O4 /MNPs/HSA/NC, CoFe2 O4 /MNPs and epirubicin‐loaded CoFe2 O4 /MNPs/HSA/NC were 7.7, 2400, 840 and 430 μg/ml, respectively. The results obtained revealed high cytotoxicity effect of epirubicin‐loaded CoFe2 O4 /MNPs on breast cancer cell line.Inspec keywords: drug delivery systems, biomedical materials, nanoparticles, cobalt compounds, ferrites, nanomedicine, proteins, molecular biophysics, drugs, magnetic particles, nanomagnetics, nanofabrication, precipitation (physical chemistry), X‐ray diffraction, X‐ray chemical analysis, scanning electron microscopy, cancer, cellular biophysics, toxicology, magnetic hysteresisOther keywords: HSA, high‐efficiency carrier, epirubicin anticancer drug delivery, human serum albumin nanocapsule, drug‐modified cobalt ferrite magnetic nanoparticle, coprecipitation technique, X‐ray powder diffraction, vibrating sample magnetometry, energy dispersive X‐ray analysis, scanning electron microscopy, map analysis, breast cancer cell line, cytotoxicity effect, CoFe2 O4 |
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