Solvothermal‐assisted green synthesis of hybrid Chi‐Fe3 O4 nanocomposites: a potential antibacterial and antibiofilm material |
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| Authors: | Palanisamy Senthilkumar Sudhagar Babu Venkatachalam Jaishree Kingsly Joshua Stephen Govindaraj Yaswant Devanesan Sanjeevi Ranjith Santhosh Kumar Nithya S Nair |
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| Affiliation: | 1. Department of Biotechnology, Kongunadu Arts and Science College, Coimbatore Tamil Nadu, India ; 2. Department of Biotechnology, PSG College of Arts and Science, Coimbatore Tamil Nadu, India ; 3. School of Biotechnology, Dr. G R Damodaran College of Science, Coimbatore Tamil Nadu, India |
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| Abstract: | In this present study, a hybrid Chi‐Fe3 O4 was prepared, characterised and evaluated for its antibacterial and antibiofilm potential against Staphylococcus aureus and Staphylococcus marcescens bacterial pathogens. Intense peak around 260 nm in the ultraviolet–visible spectrum specify the formation of magnetite nanoparticles. Spherical‐shaped particles with less agglomeration and particle size distribution of 3.78–46.40 nm were observed using transmission electron microscopy analysis and strong interaction of chitosan with the surface of magnetite nanoparticles was studied using field emission scanning microscopy (FESEM). X‐ray diffraction analysis exhibited the polycrystalline and spinel structure configuration of the nanocomposite. Presence of Fe and O, C and Cl elements were confirmed using energy dispersive X‐ray microanalysis. Fourier transform infrared spectroscopic analysis showed the reduction and formation of Chi‐Fe3 O4 nanocomposite. The antibacterial activity by deformation of the bacterial cell walls on treatment with Chi‐Fe3 O4 nanocomposite and its interaction was visualised using FESEM and the antibiofilm activity was determined using antibiofilm assay. In conclusion, this present study shows the green synthesis of Chi‐Fe3 O4 nanocomposite and evaluation of its antibacterial and antibiofilm potential, proving its significance in medical and biological applicationsInspec keywords: visible spectra, particle size, magnetic particles, nanocomposites, nanoparticles, X‐ray diffraction, nanofabrication, transmission electron microscopy, X‐ray chemical analysis, nanomagnetics, microorganisms, antibacterial activity, iron compounds, ultraviolet spectra, biomedical materials, field emission scanning electron microscopy, Fourier transform infrared spectra, filled polymers, crystal growth from solution, polymer structureOther keywords: potential antibacterial material, antibiofilm potential, magnetite nanoparticles, solvothermal‐assisted green synthesis, hybrid Chi‐Fe3 O4 nanocomposites, staphylococcus aureus, staphylococcus marcescens, bacterial pathogens, ultraviolet–visible spectrum, spherical‐shaped particles, particle size, transmission electron microscopy, FESEM, field emission scanning electron microscopy, X‐ray diffraction, spinel structure, polycrystalline structure, energy dispersive X‐ray microanalysis, Fourier transform infrared spectroscopic analysis, deformation, bacterial cell walls, Fe3 O4 |
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