| Abstract: | An accurate, safe, environmentally friendly, fast and sensitive electrochemical biosensors were developed to detect xanthine in serum. The metal‐organic framework ZIF‐8 was synthesised and elemental gold was supported on the surface of ZIF‐8 by reduction method to synthesise Ag‐ZIF‐8. The mesoporous carbon material and the synthesised Ag‐ZIF‐8 were, respectively, applied to a glassy carbon electrode to construct biosensors. The constructed biosensor has a good linear relation in the range of 1–280 μmol l−1 of xanthine and the detection limit is 0.167 μmol l−1. The relative standard deviation value in serum samples was <5%, and the recoveries were 96–106%, indicating the good selectivity, stability and reproducibility of this electrochemical biosensor.Inspec keywords: zeolites, electrochemical sensors, voltammetry (chemical analysis), mesoporous materials, biosensors, gold, reduction (chemical), nanosensors, nanofabrication, organic compounds, electrochemical electrodes, carbon, nanoparticlesOther keywords: xanthine, detection limit, serum samples, zeolitic imidazolate framework‐8, sensitive electrochemical biosensors, metal‐organic framework ZIF‐8, elemental gold, reduction method, mesoporous carbon material, glassy carbon electrode, linear relation, ordered mesoporous carbon, Ag, C |
