The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL |
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| Authors: | Patrizia Morciano Maria Laura Di Giorgio Liliana Tullo Giovanni Cenci |
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| Affiliation: | 1.INFN-Laboratori Nazionali del Gran Sasso, 67100 Assergi, Italy;2.Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Sapienza–Università di Roma, 00185 Rome, Italy; (M.L.D.G.); (L.T.);3.Fondazione Cenci Bolognetti, Istituto Pasteur, 00185 Rome, Italy |
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| Abstract: | During spermatogenesis, the Golgi apparatus serves important roles including the formation of the acrosome, which is a sperm-specific organelle essential for fertilization. We have previously demonstrated that D. melanogaster ATP-dependent Citrate Lyase (ATPCL) is required for spindle organization, cytokinesis, and fusome assembly during male meiosis, mainly due to is activity on fatty acid biosynthesis. Here, we show that depletion of DmATPCL also affects the organization of acrosome and suggest a role for this enzyme in the assembly of Golgi-derived structures during Drosophila spermatogenesis. |
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| Keywords: | Drosophila DmATPCL Golgi stacks spermatogenesis Lava lamp acroblast meiosis |
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