Redox Responsive Copolyoxalate Smart Polymers for Inflammation and Other Aging-Associated Diseases |
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Authors: | Berwin Singh Swami Vetha Angela Guma Adam Azeez Aileru |
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Affiliation: | 1.Department of Foundational Sciences and Research, School of Dental Medicine, East Carolina University, 1851 MacGregor Downs Road, MS 701, Greenville, NC 27834, USA;2.Physio/Biochem/New Product Development Division, Cocoa Research Center Institute of Ghana, P.O. Box 8, New Tafo-Akim 0233, Eastern Region, Ghana; |
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Abstract: | Polyoxalate (POx) and copolyoxalate (CPOx) smart polymers are topics of interest the field of inflammation. This is due to their drug delivery ability and their potential to target reactive oxygen species (ROS) and to accommodate small molecules such as curcumin, vanilline, and p-Hydroxybenzyl alcohol. Their biocompatibility, ultra-size tunable characteristics and bioimaging features are remarkable. In this review we discuss the genesis and concept of oxylate smart polymer-based particles and a few innovative systemic delivery methods that is designed to counteract the inflammation and other aging-associated diseases (AADs). First, we introduce the ROS and its role in human physiology. Second, we discuss the polymers and methods of incorporating small molecule in oxalate backbone and its drug delivery application. Finally, we revealed some novel proof of concepts which were proven effective in disease models and discussed the challenges of oxylate polymers. |
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Keywords: | copolyoxalate smart polymer reactive oxygen species polymeric drug delivery nanodrug delivery aging-associated diseases |
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