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A Highly Active 4‐Siloxyproline Catalyst for Asymmetric Synthesis |
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| Authors: | Yujiro Hayashi Junichiro Yamaguchi Kazuhiko Hibino Tatsunobu Sumiya Tatsuya Urushima Mitsuru Shoji Daisuke Hashizume Hiroyuki Koshino |
| Abstract: | trans‐4‐tert‐Butyldimethylsiloxy‐L ‐proline displays a greater catalytic activity than the parent proline without compromising the enantioselectivity, which widens the substrate scope in the α‐aminoxylation of carbonyl compounds, as well as O‐nitroso‐aldol/Michael, and Mannich reactions. |
| Keywords: | asymmetric synthesis Mannich reaction organic catalysis oxidation proline |