| 金属及金属氧化物纳米材料的放射性标记 |
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| 引用本文： | 芮玉奎,张艳北,桂新,金婷婷,张智勇. 金属及金属氧化物纳米材料的放射性标记[J]. 同位素, 2013, 26(1): 8-15. DOI: 10.7538/tws.2013.26.01.0008 |
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| 作者姓名： | 芮玉奎 张艳北 桂新 金婷婷 张智勇 |
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| 作者单位： | 中国农业大学资源与环境学院;中国科学院高能物理研究所核分析技术重点实验室纳米生物效应与安全性重点实验室 |
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| 基金项目： | 科技部973项目(2011CB933400);国家自然科学基金项目(11005118,11275215) |
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| 摘 要： | 纳米生物学、纳米医学和纳米毒理学是伴随着纳米技术发展而出现的新兴交叉学科，如何实现生物体内纳米材料的定量检测是目前面临的共同难题。放射性同位素示踪技术由于具有灵敏度高、准确度好、测量简便、干扰少等特点，特别适合于此类研究。本文综述了6种重要的金属和金属氧化物纳米材料（纳米金、纳米银、纳米氧化铁、纳米二氧化钛、纳米二氧化铈和纳米氧化锌）的放射性标记方法，分析了不同方法的优缺点和注意事项。
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| 关 键 词： | 金属和金属氧化物纳米材料 放射性标记 纳米生物学 纳米医学 纳米毒理学 |
Radiolabeling of Metallic and Metal Oxide Nanomaterials |
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| RUI Yu-kui,ZHANG Yan-bei,GUI Xin,JIN Ting-ting,ZHANG Zhi-yong. Radiolabeling of Metallic and Metal Oxide Nanomaterials[J]. Isotopes, 2013, 26(1): 8-15. DOI: 10.7538/tws.2013.26.01.0008 |
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| Authors: | RUI Yu-kui ZHANG Yan-bei GUI Xin JIN Ting-ting ZHANG Zhi-yong |
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| Affiliation: | 1. College of Environment of Resources, China Agricultural University, Beijing 100193, China;2. Key Laboratory of Nuclear Analytical Techniques, and Key Laboratory of Biomedical Effects of Nanomaterials and Nano-safety, The Chinese Academy of Sciences, Institute of High Energy Physics, Beijing 100049, China |
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| Abstract: | Nanobiology, nanomedicine, and naontoxicology are newly developed interdisciplinary research fields accompanied by the development of nanotechnology. Quantitative determination of nanomaterials in vivo is the common problem that is experienced by these disciplines. Radiotracer techniques had the advantage of high sensitivity, good accuracy, simplicity and low interference. This review describes radiolabeling methods of 6 important metallic and metal oxide nanomaterials, such as gold, silver, iron oxide, titanium oxide, and zinc oxide nanoparticles. Advantage, disadvantage, and caution of each method are summarized. |
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| Keywords: | metallic and metal oxide nanomaterials radiolabeling nanobiology nanomedicine naontoxicology |
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