| 先天性大疱性表皮松解症的超微病理诊断 |
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| 引用本文： | 汤秀英,朱学骏,任雅丽,王书合,柴立军,程明. 先天性大疱性表皮松解症的超微病理诊断[J]. 电子显微学报, 2010, 29(5): 482-485 |
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| 作者姓名： | 汤秀英 朱学骏 任雅丽 王书合 柴立军 程明 |
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| 作者单位： | 1. 北京大学第一医院电镜室,北京,100034
2. 北京大学第一医院皮肤性病科,北京,100034 |
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| 摘 要： | 目的：应用电镜观察先天性大疱性表皮松解症（EB）的超微结构特点并进行分类诊断。方法：按电镜常规进行标本制备,应用透射电镜对22例EB的皮肤活检进行超微结构观察。结果：超微病理诊断单纯型（EBS）15例,交界型（JEB）1例,营养不良型（DEB）6例。EBS的表皮基底层见水疱和裂隙样结构,基底层细胞变性及空泡形成,张力丝断裂、缩短及凝聚。JEB的水泡在基底膜的透明板,半桥粒发育不良、数目减少。DEB水疱位于真皮内,锚纤维缩短、减少。结论：电镜超微病理观察对EB的分类诊断有重要的辅助诊断价值。
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| 关 键 词： | 表皮松解症 超微病理 电镜 |
The ultrapathological diagnosis of epidermolysis bullosa |
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| TANG Xiu-ying,ZHU Xue-jun,Ren Ya-li,WANG Shu-he,CHAI Li-jun,CHENG Ming. The ultrapathological diagnosis of epidermolysis bullosa[J]. Journal of Chinese Electron Microscopy Society, 2010, 29(5): 482-485 |
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| Authors: | TANG Xiu-ying ZHU Xue-jun Ren Ya-li WANG Shu-he CHAI Li-jun CHENG Ming |
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| Affiliation: | TANG Xiu-ying1,ZHU Xue-jun2,Ren Ya-li1,WANG Shu-he1,CHAI Li-jun1,CHENG Ming1(1.Lab of Electron Microscopy,2.Department of Dermatology,Peking University First Hospital,Beijing 100034,China) |
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| Abstract: | Objective: To study the ultrapathological and diagnosis classification of epidermolysis bullosa(EB) by using electron microscopy.Methods: The skin biopsy specimens were obtained from 22 patients with EB and processed by routine thinsection electron microscopy.Results: Under electron microscopy,22 cases were diagnosis as having 15 cases of epidermolysis bullosa simplex(EBS),1 case of junctional epidermolysis bullosa(JEB),and 6 cases of dystrophic epidermolysis bullosa(DEB).In EBS,the vesicles of various size... |
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| Keywords: | epidermolysis bullosa ultrapathology electron microscopy |
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