杏鲍菇多糖对老龄小鼠抗疲劳能力的影响

目的：研究杏鲍菇多糖对老龄小鼠游泳耐力和相关生理指标的影响。方法：将小鼠随机分为对照组(A)、衰老模型组(B)、衰老用糖组(C)。 B、C 组腹腔注射D- 半乳糖(100mg/(kg bw·d))，连续60d，建立衰老模型，A 组腹腔注射生理盐水，剂量时程相同；第41 天起C 组灌胃100mg/(kg bw·d)杏鲍菇多糖，A、B 组灌胃等剂量蒸馏水，连续20d。第61 天测定小鼠的力竭游泳时间、血尿素氮、血乳酸值、血红蛋白含量及脏器指数。结果：杏鲍菇多糖能显著降低运动后血尿素氮和血乳酸含量，延长力竭游泳时间，并使血红蛋白含量及胸腺、脾脏指数显著提高(P ＜ 0.05)。结论：杏鲍菇多糖具有抗疲劳、提高老龄小鼠运动能力的功效。

Anti-fatigue Effect of Polysaccharides from Pleurotus eryngii in Aged Mice

Objective: To study the anti-fatigue effect of Pleurotus eryngii polysaccharides in aged mice. Methods: Healthy male Kunming mice were randomly divided into control group (A), aging model group (B) and Pleurotus eryngii polysaccharide treated aging group (C). The mice in Group B and C were intraperitoneally injected D-galactose at the dose of 100 mg/(kg bw·d) and those in Group A were intraperitoneally injected at the same volume of saline for 60 consecutive days. The mice in Group C were administered Pleurotus eryngii polysaccharides at the dose of 100 mg/(kg bw·d) and the mice in Group A and B were given distilled water from day 41. After the administration for 20 consecutive days, all mice were subjected to exhaustive swimming and exhaustive swimming time was recorded. Meanwhile, blood was harvested for determining the contents of blood urea nitrogen, lactate and hemoglobin and organ indexes were also measured. Results: The fungal polysaccharides prolonged exhaustive swimming time of aged mice, decreased blood urea nitrogen and lactate levels, and significantly increased hemoglobin content, red blood cell number, and thymus and spleen indexes. Conclusion: Pleurotus eryngii polysaccharides have an obvious anti-fatigue effect and improve exercise capacity of mice.