Preparation and characterization of carnauba wax nanostructured lipid carriers containing benzophenone-3 |
| |
Authors: | Lacerda S P Cerize N N P Ré M I |
| |
Affiliation: | Post-Graduate program in Pharmacy, Federal University of Pernambuco, Recife-PE, Brazil. |
| |
Abstract: | Nanostructured lipid carriers (NLCs) are potential active delivery systems based on mixtures of solid lipids and liquid oil. In this paper, aqueous dispersions of NLCs were prepared by a hot high-pressure homogenization technique using carnauba wax as the solid lipid and isodecyl oleate as the liquid oil. The preparation and stability parameters of benzophenone-3-loaded NLCs have been investigated concerning particle size, zeta potential and loading capacity to encapsulate benzophenone-3, a molecular sunscreen. The current investigation illustrates the effect of the composition of the lipid mixture on the entrapment efficiency, in vitro release and stability of benzophenone-3-loaded in these NLCs. A loading capacity of approximately 5% of benzophenone-3 (m(BZ-3) /m(lipids) ) was characteristic of these systems. |
| |
Keywords: | benzophenone‐3 carnauba wax dispersions isodecyl oleate nanostructured lipid carriers |
本文献已被 PubMed 等数据库收录! |
|