Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units |
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Authors: | M Angiolini L Belvisi D Poma A Salimbeni N Sciammetta C Scolastico |
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Affiliation: | University of Milano, Organic and Industrial Chemistry Department, C.N.R. Centre for the Study of Organic and Natural Compounds, Italy. |
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Abstract: | Extensive molecular modelling studies, including conformational analysis and the comparison of molecular electrostatic potential distributions, wee used to evaluate structural parameters of new antagonists containing acyclic replacements of the N = C-N imidazole region. The synthesis and the biological screening of a series of acyl biphenyltetrazole derivatives were planned and realized to gain an insight into the structure-activity relationships of this unusual class of Angiotensin II antagonists. |
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