The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer |
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| Authors: | Patrycja Kł os,Siarhei A. Dabravolski |
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| Affiliation: | 1.Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Al. Powstańców Wlkp., 70-111 Szczecin, Poland;2.Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora Str., 210026 Vitebsk, Belarus |
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| Abstract: | Inflammatory bowel disease (IBD) is one of the leading gut chronic inflammation disorders, especially prevalent in Western countries. Recent research suggests that mitochondria play a crucial role in IBD development and progression to the more severe disease—colorectal cancer (CRC). In this review, we focus on the role of mitochondrial mutations and dysfunctions in IBD and CRC. In addition, main mitochondria-related molecular pathways involved in IBD to CRC transition are discussed. Additionally, recent publications dedicated to mitochondria-targeted therapeutic approaches to cure IBD and prevent CRC progression are discussed. |
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| Keywords: | inflammatory bowel diseases colorectal cancer chronic inflammation mitochondrial dysfunction mitochondrial mutations |
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