Direct-write assembly of silicate and borate bioactive glass scaffolds for bone repair |
| |
Authors: | Aylin M Deliormanl? Mohamed N Rahaman |
| |
Affiliation: | 1. Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China;2. Shanghai 6th People''s Hospital, Shanghai Jiaotong University, Shanghai 200233, China;3. Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China;4. Department of Materials Science and Engineering, Center for Biomedical Science and Engineering, Missouri University of Science and Technology, MO 65409-0340, USA;1. Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada;2. Department of Chemical Engineering, McGill University, Montreal, QC, Canada |
| |
Abstract: | Silicate (13-93) and borate (13-93B3) bioactive glass scaffolds were created by robotic deposition (robocasting) of organic solvent-based suspensions and evaluated in vitro for potential application in bone repair. Suspensions (inks) were developed, characterized, and deposited layer-by-layer to form three-dimensional scaffolds with a grid-like microstructure (porosity ≈50%; pore width 420 ± 30 μm). The mechanical response of the scaffolds was tested in compression, and the conversion of the glass to hydroxyapatite (HA)-like material in a simulated body fluid (SBF) was evaluated. As fabricated, the 13-93 scaffolds had a compressive strength 142 ± 20 MPa, comparable to the strength of human cortical bone, while the strength of the 13-93B3 scaffolds (65 ± 11 MPa), was far higher than that for trabecular bone. When immersed in SBF, the borate 13-93B3 scaffolds converted faster than the silicate 13-93 scaffolds to an HA-like material, but they also showed a sharper decrease in strength with immersion time. Based on their high compressive strength and bioactivity, the scaffolds fabricated in this work by robocasting could have potential application in the repair of load-bearing bone. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|