淀粉纤维的成形及其载药控释研究进展

为制备孔隙率高、比表面积大、药物释放性能可控的载药淀粉纳米纤维,促进其在载药外敷等生物医学领域中的应用,从淀粉纤维的成形及其载药控释2个方面进行综述。首先,系统介绍了近年来国内外关于淀粉纤维的制备方法与工艺特点。针对淀粉纤维的成形机制,详细阐述了改性淀粉基纤维、共混淀粉基纤维、纯淀粉纤维的发展进程、性能特点及研究进展;针对载药淀粉纳米纤维在药物释放过程出现初始爆发释放的问题,介绍了交联改性等方法对淀粉纳米纤维膜载药控释性能的影响。最后,对淀粉纳米纤维在载药外敷领域所面临的困难和挑战提出了应对策略,并对其未来的研究方向进行展望。

Research progress in formation of starch fibers and their drug-loaded controlled-release

In order to prepare drug-loaded starch nanofibers with high porosity, large specific surface area and controllable drug release properties, and promote their application in biomedical fields such as drug-loaded dressings, this paper mainly reviewed on starch fibers formation and drug loading and controlled release of the starch fibers. The preparation methods and processing characteristics of starch fibers in recent researches were systematically introduced. In view of the formation of starch fibers, the development process, performance characteristics and research progress of modified starch-based fibers, blended starch-based fibers and pure starch fibers were introduced in details. Regarding the problem of initial burst release of drug-loaded starch nanofibers in the drug release process, the influence of cross-linking methods on controlled drug release performance of starch nanofibers membrane was reviewed. Finally, the countermeasures for the difficulties and challenges faced by starch nanofibers in drug-loaded external dressings were presented, and the future research directions were proposed.