| 纳米羟基磷灰石及其复合材料作为药物载体的研究进展 |
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| 引用本文： | 卢英,荀晓伟,杨志伟,罗红林,万怡灶,左桂福.纳米羟基磷灰石及其复合材料作为药物载体的研究进展[J].复合材料学报,2020,37(12):2953-2965. |
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| 作者姓名： | 卢英 荀晓伟 杨志伟 罗红林 万怡灶 左桂福 |
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| 作者单位： | 1.华东交通大学 先进材料研究院 江西省纳米生物材料重点实验室，南昌 330013 |
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| 基金项目： | 国家自然科学基金 (51662009；31660264)；江西省教育厅科学技术研究项目(GJJ180348) |
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| 摘 要： | 纳米羟基磷灰石(HAp)具有良好的生物活性和药物吸附性，是一种理想的无机药物载体。本文从生物安全性、抗肿瘤活性和药物吸附性三个方面阐述了纳米HAp的载药特性，探讨了其微观形貌对载药性能的影响，对载药纳米HAp复合材料的分类、制备及载药和释药性能进行了系统综述，旨在为纳米HAp及其复合材料在药物载体领域的应用提供理论基础。
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| 关 键 词： | 纳米羟基磷灰石 药物载体 复合材料 微观形貌 药物吸附/释放 |
| 收稿时间： | 2020-06-22 |
Research progress of nano-hydroxyapatite and its composite materials as drug carriers |
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| Affiliation: | 1.Jiangxi Provincial Key Laboratory of Nanometer Biomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang 330013, China2.School of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063210, China |
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| Abstract: | Nano-hydroxyapatite (HAp) is an ideal inorganic drug carrier due to its good biological activity and drug adsorption ability. In this paper, the drug loading performance of nano-HAp was described by three aspects: Biological safety, antitumor activity and drug adsorption. Moreover, the effect of HAp micromorphology on drug-loading performance was also discussed. Furthermore, the classification, preparation, drug loading and drug release of nano-HAp composites were systematic reviewed, which aimed to provide a theoretical basis for application as drug carrier of nano-HAp and its composites. |
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