Optimization studies on floating multiparticulate gastroretentive drug delivery system of famotidine |
| |
Authors: | Gupta Reshu Pathak Kamla |
| |
Affiliation: | Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, India. |
| |
Abstract: | The objective of this study was to optimize floating microballoons of famotidine by the emulsion solvent diffusion technique using central composite design. Formulations F1-F15 were prepared using three independent variables (pH of medium, drug: Eudragit S100 ratio and ethanol : dichloromethane ratio) and evaluated for dependent variables (shape, percentage buoyancy, and encapsulation). The optimized formulation F9 was fractionated and a polymer combination of (Eudragit S100 : Eudragit L100-55, 9.5:0.5) resulted in microballoons that exhibited zero order release (94.73%) with 84.20% buoyancy at the end of the eighth hour when studied in the mesh-designed modified USP type II apparatus. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|