Recent progress in injectable bone repair materials research |
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Authors: | Zonggang Chen Xiuli Zhang Lingzhi Kang Fei Xu Zhaoling Wang Fu-Zhai Cui Zhongwu Guo |
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Affiliation: | 1. National Glycoengineering Research Center, Shandong University, Jinan 250100, China2. Key Laboratory of Oral and Maxillofacial Medical Biology, Liaocheng People’s Hospital, Liaocheng 252000, China3. Jinan Military General Hospital of PLA, Jinan 250031, China4. School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China |
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Abstract: | Minimally invasive injectable self-setting materials are useful for bone repairs and for bone tissue regeneration in situ. Due to the potential advantages of these materials, such as causing minimal tissue injury, nearly no influence on blood supply, easy operation and negligible postoperative pain, they have shown great promises and successes in clinical applications. It has been proposed that an ideal injectable bone repair material should have features similar to that of natural bones, in terms of both the microstructure and the composition, so that it not only provides adequate stimulus to facilitate cell adhesion, proliferation and differentiation but also offers a satisfactory biological environment for new bone to grow at the implantation site. This article reviews the properties and applications of injectable bone repair materials, including those that are based on natural and synthetic polymers, calcium phosphate, calcium phosphate/polymer composites and calcium sulfate, to orthopedics and bone tissue repairs, as well as the progress made in biomimetic fabrication of injectable bone repair materials. |
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Keywords: | bone repair material polymer calcium phosphate calcium sulfate biomimetic |
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